San Francisco, officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area, a region of 7.5 million people which includes San Jose and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121 km2) on the northern end of the San Francisco Peninsula, giving it a density of about 17,179 people per square mile (6,632 people per km2). It is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated large city in the United States after New York City. San Francisco is the fourth most populous city in California and the 13th most populous city in the United States, with a population of 805,235 as of the 2010 Census. The San Francisco-Oakland-Fremont metropolitan area has a population of 4,335,391.

Victoria, capital of British Columbia, is located near the southern tip of Vancouver Island. With abundant parkland, it’s known for outdoor activities. Named after Queen Victoria of the United Kingdom and, at the time, British North America, Victoria is one of the oldest cities in the Pacific Northwest, with British settlement beginning in 1843. Known as the "The Garden City", Victoria is also an attractive city and a popular tourism destination with a thriving technology sector that has risen to be its largest revenue-generating private industry.

Seattle is the northernmost major city in the contiguous United States, and the largest city in the Pacific Northwest and in the state of Washington. A seaport situated on a narrow isthmus between Puget Sound (an arm of the Pacific Ocean) and Lake Washington, about 100 miles (160 km) south of the Canada – United States border, it is named after Chief Sealth "Seattle", of the Duwamish and Suquamish native tribes. Seattle is the center of the Seattle–Tacoma–Bellevue metropolitan statistical area, the 15th largest in the United States, and the largest in the northwestern United States. Seattle is the county seat of King County and is the major economic, cultural and educational center in the region. The 2010 census found that Seattle is home to 630,320 residents within a metropolitan area of some 3.4 million inhabitants. The Port of Seattle and Seattle–Tacoma International Airport are major gateways to Asia, Alaska, and the rest of the world.

Ketchikan is an Alaskan city facing the Inside Passage, a popular cruise route along the state's southeastern coast. The city is named after Ketchikan Creek, which flows through the town, emptying into the Tongass Narrows a short distance southeast of its downtown. Civic boosters have dubbed the community the "Salmon Capital of the World". The Misty Fiords National Monument is one of the area's major attractions, and the Tongass National Forest has long been headquartered in Ketchikan, mostly in the city's historic Federal Building.

Yokohama is the second largest city in Japan by population, and most populous municipality of Japan. It is the capital city of Kanagawa Prefecture. It lies on Tokyo Bay, south of Tokyo, in the Kantō region of the main island of Honshu. It is a major commercial hub of the Greater Tokyo Area. It’s also known for Sankei-en Garden, a botanical park containing preserved Japanese residences from different eras, and the seaside Minato Mirai district, site of the 296m Landmark Tower.   Yokohama's population of 3.7 million makes it Japan's largest city after the Special Wards of Tokyo. Yokohama developed rapidly as Japan's prominent port city following the end of Japan's relative isolation in the mid-19th century, and is today one of its major ports along with Kobe, Osaka, Nagoya, Hakata, Tokyo, and Chiba.