Victoria, capital of British Columbia, is located near the southern tip of Vancouver Island. With abundant parkland, it’s known for outdoor activities. Named after Queen Victoria of the United Kingdom and, at the time, British North America, Victoria is one of the oldest cities in the Pacific Northwest, with British settlement beginning in 1843. Known as the "The Garden City", Victoria is also an attractive city and a popular tourism destination with a thriving technology sector that has risen to be its largest revenue-generating private industry.

The City and Borough of Juneau is a unified municipality located on the Gastineau Channel in the panhandle of the U.S. state of Alaska. It has been the capital of Alaska since 1906, when the government of the then-District of Alaska was moved from Sitka as dictated by the U.S. Congress in 1900. Juneau is home to Perseverance Theatre, Alaska's only professional theater. The city hosts the annual Alaska Folk Festival and Juneau Jazz & Classics music festivals, and the biennial Celebration. The Juneau Symphony performs regularly. Downtown Juneau boasts dozens of art galleries, which participate in the monthly First Friday Gallery Walk and the enormously popular December Gallery Walk held in the first week of December. The Juneau Arts & Humanities Council coordinates events while fund-raising, distributing some grant money, and operating a gallery at its office in the Juneau Arts & Culture Center, 350 Whittier Street. On summer Friday evenings open-air music and dance performances are held at Marine Park.

Seattle is the northernmost major city in the contiguous United States, and the largest city in the Pacific Northwest and in the state of Washington. A seaport situated on a narrow isthmus between Puget Sound (an arm of the Pacific Ocean) and Lake Washington, about 100 miles (160 km) south of the Canada – United States border, it is named after Chief Sealth "Seattle", of the Duwamish and Suquamish native tribes. Seattle is the center of the Seattle–Tacoma–Bellevue metropolitan statistical area, the 15th largest in the United States, and the largest in the northwestern United States. Seattle is the county seat of King County and is the major economic, cultural and educational center in the region. The 2010 census found that Seattle is home to 630,320 residents within a metropolitan area of some 3.4 million inhabitants. The Port of Seattle and Seattle–Tacoma International Airport are major gateways to Asia, Alaska, and the rest of the world.

Ketchikan is an Alaskan city facing the Inside Passage, a popular cruise route along the state's southeastern coast. The city is named after Ketchikan Creek, which flows through the town, emptying into the Tongass Narrows a short distance southeast of its downtown. Civic boosters have dubbed the community the "Salmon Capital of the World". The Misty Fiords National Monument is one of the area's major attractions, and the Tongass National Forest has long been headquartered in Ketchikan, mostly in the city's historic Federal Building.

Skagway is a first-class borough in Alaska on the Alaska Panhandle. The port of Skagway is a popular stop for cruise ships, and the tourist trade is a big part of the business of Skagway. The White Pass and Yukon Route narrow gauge railroad, part of the area's mining past, is now in operation purely for the tourist trade and runs throughout the summer months. Skagway is also part of the setting for Jack London's book The Call of the Wild and for Joe Haldeman's novel Guardian.