Rhodes is the largest of the Dodecanese islands in terms of land area and also the island group's historical capital. Administratively the island forms a separate municipality within the Rhodes regional unit, which is part of the South Aegean administrative region. It is located northeast of Crete, southeast of Athens and just off the Anatolian coast of Turkey. Rhodes' nickname is The island of the Knights, named after the Knights of Saint John of Jerusalem, who once conquered the land. Historically, Rhodes was famous worldwide for the Colossus of Rhodes, one of the Seven Wonders of the Ancient World. The Medieval Old Town of the City of Rhodes has been declared a World Heritage Site. Today, it is one of the most popular tourist destinations in Europe.

Haifa is the third-largest city in the State of Israel. It is home to the Bahá'í World Centre, a UNESCO World Heritage Site and a destination for Baha'i pilgrims. Built on the slopes of Mount Carmel, the settlement has a history spanning more than 3,000 years. The earliest known settlement in the vicinity was Tell Abu Hawam, a small port city established in the Late Bronze Age (14th century BCE). In the 3rd century CE, Haifa was known as a dye-making center. Today, the city is a major seaport located on Israel's Mediterranean coastline in the Bay of Haifa covering 63.7 square kilometres (24.6 sq mi). The city plays an important role in Israel's economy. It is also home to Matam, one of the oldest and largest high-tech parks in the country. Haifa Bay is a center of heavy industry, petroleum refining and chemical processing. Haifa formerly functioned as the western terminus of an oil pipeline from Iraq via Jordan.

Port Said is a city that lies in north east Egypt along the coast of the Mediterranean Sea. The city was established in 1859 during the building of the Suez Canal. It thrives on being a duty-free port, as well as a tourist resort especially during summer. It is also home to the Lighthouse of Port Said (the first building in the world built from reinforced concrete). There are numerous old houses with grand balconies on all floors, giving the city a distinctive look. Port Said's twin city is Port Fuad, which lies on the eastern bank of the canal. The cities are connected by free ferries running all through the day, and together they form a metropolitan area with over a million residents that extends both on the African and the Asian sides of the Suez Canal. The only other metropolitan area in the world that also spans two continents is Istanbul. Port Said acted as a global city since its establishment and flourished particularly during the nineteenth and the first half of the twentieth century when it was inhabited by various nationalities and religions. Most of them were from Mediterranean countries, and they coexisted in tolerance, forming a cosmopolitan community.

Alexandria is the second largest city and a major economic centre in Egypt, extending about 32 km (20 mi) along the coast of the Mediterranean Sea in the north central part of the country. It is Egypt's largest seaport, serving approximately 80% of Egypt's imports and exports. It is an important industrial center because of its natural gas and oil pipelines from Suez. The city is also an important tourist destination and is worth a visit for its many cultural attractions and still-palpable glimpses of its past.

Piraeus is a city in the periphery of Attica,  Greece and within the Athens urban area, located 12 km southwest of its center and upon the Saronic Gulf. According to the 2001 census, Piraeus has a population of 175,697 people within its administrative limits, making it the third largest municipality in Greece and the second within the Greek capital following the municipality of Athens. The Piraeus urban area extends beyond the administrative city limits to the suburban municipalities, with a total population of 466,065. 

Sorrento Neapolitan: Surriento is a town overlooking the Bay of Naples in Southern Italy. A popular tourist destination, it can be reached easily from Naples and Pompeii as it is at the south-eastern end of the Circumvesuviana rail line. The Sorrentine Peninsula has views of Naples, Vesuvius and the Isle of Capri. The Amalfi Drive, connecting Sorrento and Amalfi, is a narrow road that threads along the high cliffs above the Tyrrhenian Sea.

Civitavecchia is a town and comune of the Metropolitan City of Rome in the central Italian region of Lazio. A sea port on the Tyrrhenian Sea, the name ''Civitavecchia'' means "ancient town". The modern city was built over a pre-existing Etruscan settlement. The massive Forte Michelangelo was first commissioned from Donato Bramante by Pope Julius II, to defend the port of Rome. The upper part of the "maschio" tower, however, was designed by Michelangelo, whose name is generally applied to the fortress. North of the city at Ficoncella are the Terme Taurine baths frequented by Romans and still popular with the Civitavecchiesi. The modern name stems from the common fig plants among the various pools. And also next to the town is the location of the cruise ship docks. All major cruise lines start and end their cruises at this location, and others stop for shore excursion days that allow guests to see Rome and Vatican sights, which are ninety minutes away.